CLEC-1 : Novel Don’t Eat Me signal Regulating Anti-Tumor Responses

Time: 2:00 pm
day: Discovery & Pre-Clinical Development - Day 1 pm


  • CLEC-1 inhibits dendritic cells antigen cross-presentation and macrophage phagocytosis in synergy with tumortargeting mAb
  • Cell stress/death induced by radiation or chemotherapy increased CLEC-1 ligand expression
  • Increased anti-tumor responses in vivo in CLEC-1 KO mice and synergy with chemotherapy