Macrophage Repolarization is Capable of Inflaming Tumor Microenvironment

Time: 2:30 pm
day: Clinical Development – Day 2 pm


  • Tumors evolve the ability to induce and maintain a microenvironment capable of shielding it from immune surveillance. Macrophage repolarization is capable of shifting the polarity of the tumor microenvironment away from tolerance and toward an immune attack. Given the prevalence of human tumors highly infiltrated with tolerogenic macrophages, targeting them is a potent strategy to broaden the clinical reach of what was possible with T cell checkpoint inhibitors