Reprogramming Human Macrophages to Achieve Anti-Tumor Immune Response.
Time: 4:30 pm
day: Discovery & Pre-Clinical Development - Day 1 pm2
- Macrophages adopt functional roles in response to signals from their environment. Tumor-associated macrophages (TAMs) are regulators of interactions between immune system and cancer, they fuel tumor progression, but impact responses to therapy.
- We found novel targets that change macrophages into anti-tumor response enablers and validated targets modulating human macrophage biology.
- Verseau lead programs reprogram macrophages to a pro-inflammatory state, activates T cells, and attracts immune cells to generate anti-tumor responses.