Small Molecule GPR65 Inhibitors Reverse Acidosis-Induced Immunosuppression in Macrophages and Suppresses Tumor Growth in vivo Via an Elevation of Natural Killer (NK) Cells
Time: 1:30 pm
day: Day One Track A PM
Details:
- Solid tumors are typically more acidic than surrounding normal tissue
- This acidity activates GPR65 on macrophages, causing a suppression pro-inflammatory cytokines and chemokines
- Small molecule GPR65 inhibitors counteract this effect and reduce tumor growth in vivo through an increase in the infiltration of key effector cells
