Small Molecule GPR65 Inhibitors Reverse Acidosis-Induced Immunosuppression in Macrophages and Suppresses Tumor Growth in vivo Via an Elevation of Natural Killer (NK) Cells

Time: 1:30 pm
day: Day One Track A PM

Details:

  • Solid tumors are typically more acidic than surrounding normal tissue 
  • This acidity activates GPR65 on macrophages, causing a suppression pro-inflammatory cytokines and chemokines  
  • Small molecule GPR65 inhibitors counteract this effect and reduce tumor growth in vivo through an increase in the infiltration of key effector cells 

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