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Courtney Crane

Courtney Crane

Company: Seattle Children’s Hospital

Job title: Principal Investigator

Bio:

Courtney Crane received her PhD in the lab of Dr. Margo Roberts (former CSO at Kite Pharma), and did her postdoctoral work at the University of California in San Francisco with Dr. Lewis Lanier, a world renowned NK cell biologist, and Dr. Andrew Parsa, a neurosurgeon scientist. There she developed an interest in how solid tumors used macrophages to support tumor growth while suppressing immune responses. Using their inherent biology of tumor infiltration and residence, the Crane Lab uses genetic modification of macrophages to make tumors visible to the immune system while supporting endogenous immune cells to kill tumor cells.

Seminars:

Testing Genetically Engineered Macrophages to Transform the Solid Tumor Microenvironment 12:00 pm

• Outline pre-clinical genetically modified macrophage data and path to clinic • Discuss additional payloads for future and combination approaches • Considerations for mechanistic insight in clinical trials to inform future designRead more

day: Day Two

Panel Discussion: Defining Metrics of Success with Macrophage-directed Therapeutics 9:30 am

Key questions to address: • What does success look like when manipulating macrophage phenotypes? • Is success defined through restructuring the tumor microenvironment or activating t cell infiltration to the tumor site? • What will be the most relevant strategy clinically addressing macrophages? • Define the most important parameters around this modality that will reflect…Read more

day: Day Two

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