Stuart Hughes

Company: Pathios Therapeutics

Job title: Chief Executive Officer

Seminars:

Small Molecule GPR65 Inhibitors Reverse Acidosis-Induced Immunosuppression in Macrophages and Suppresses Tumor Growth in vivo Via an Elevation of Natural Killer (NK) Cells 1:30 pm

Solid tumors are typically more acidic than surrounding normal tissue  This acidity activates GPR65 on macrophages, causing a suppression pro-inflammatory cytokines and chemokines   Small molecule GPR65 inhibitors counteract this effect and reduce tumor growth in vivo through an increase in the infiltration of key effector cells Read more

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