Stuart Hughes

Stuart Hughes

Company: Pathios Therapeutics

Job title: CEO


Pro-Tumourigenic Polarisation Of Human Macrophages By Low Ph Is Fully Reversed By Small Molecule Inhibitors Of GPR65: Implications For Immunotherapy 3:00 pm

Tumour-associated macrophages are typically protumourigenic, exhibiting a Th2 activation signature and supporting angiogenesis and tissue growth The adoption of this phenotype in the tumour can be fully explained by the impact of low ph on macrophage gene expression acting via the pH-dependent GPCR, GPR65 This polarisation can thus be fully reversed by novel, small molecule…Read more

day: Discovery & Pre-Clinical Development - Day 1 pm

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