Michael Brehm

Company: UMass Chan Medical School

Job title: Associate Professor

Seminars:

Round Table Discussion:Moving Beyond Animal Models 12:00 pm

Following novel FDA guidance, explore the range of non-animal preclinical models to discuss applications for macrophage therapies Discuss various applications of in vivo and ex vivo models to macrophage therapies and advantages of each How can we leverage next-generation tumoroid and organoid models to demonstrate preclinical proof of concept and safety?Read more

day: Day One

Utilizing Effective Models That Recapitulate Human Macrophages to Determine Mechanism of Action in the Preclinical Setting 11:30 am

Applying macrophage and tumor biology to animal models to create a recapitulative environment to an in vivo human setting Employing humanized mice with tumor grafts to demonstrate clinical proof of concept Distinguishing areas for improvement to shape and overcome hurdles in current modelsRead more

day: Day One