Takatoshi Soga

Takatoshi Soga

Company: United Immunity

Job title: Senior Vice President, Research


Overcoming Hostile Tumor Microenvironment With UI-102, a Pullulan Nanoparticle DDS-Encapsulated TLR7/8 Agonist That Actively Targets DCSIGN- Expressing M2-Like Tumor-Associated Macrophages 2:00 pm

UI-102 significantly enhanced the efficacy of PD-1 and PD-L1 inhibitors in murine tumor models that are treatment resistant to checkpoint inhibitors UI-102 promoted polarization of M2-like tumor-associated macrophages (TAMs) into M1 resulting in the conversion of refractory “cold” tumors onto “hot” ones and increased recruitment of CD8+ T cells and NK cells into tumors Pullulan…Read more

day: Conference Day One

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