9.00am - 5.00pm EST | 6.00am - 2.00pm PST

9:00 am Coffee & Networking

9:30 am Chairman’s Opening Remarks

Exploring the Use of Macrophages as Cellular Therapy to Accelerate the Development of Solid Tumor Treatment

9:45 am Genetically Engineering CAR Macrophages & CAR Monocytes: A New Direction for Cellular Immunotherapy

Antibody Based Disruption of Macrophages for Anti-Tumor Effects

10:15 am Heterogeneity of Suppressive Mechanisms Employed by TumorAssociated Macrophages & their Relationship with Currently Approved PD-1 Inhibitors

  • Igor Feldman Vice President, Head of Computational Biology, Verseau Therapeutics

10:45 am Relearning the Biology of Macrophages in Tumors to Accelerate Development of Next Generation Anti-Tumor Treatment

  • Leonard Reyno Chief Executive Officer , Pionyr Immunotherapeutics

11:15 am Generation & Characterization of Tumor-Specific CD24 Monoclonal Antibody for Immunotherapy

11:45 am Morning Break & Networking

Optimizing Polarization Approaches to Induce Anti-Tumor Immune Responses

12:15 pm Completing the Immune Cycle by Targeting Novel Macrophage Checkpoints

12:45 pm Targeting Macrophages in Breast Cancer

  • Jennifer Guerriero Instructor in Medicine, Director, Harvard Medical School, Breast Tumor Immunology Laboratory, Dana- Farber Cancer Institute

1:15 pm Reprograming Macrophages with Selective Targeting by Small Molecule Therapeutics

1:45 pm Lunch

Optimizing Polarization Approaches to Induce Anti-Tumor Immune Responses

2:45 pm Backpacks: Disc-Shaped Particles to Guide & Sustain Macrophage Phenotypes for Anti-Tumor Therapies

  • C. Wyatt Shields IV Assistant Professor , Department of Chemical and Biological Engineering, University of Colorado Boulder

3:15 pm Modulation of the pro-tumor functions of macrophages in the clinic

Addressing the Manufacturing & Process Development Challenges

3:45 pm Rapid 48-Hour Pro-resolving Monocyte/Macrophage (MΦ) Polarization at Higher Volumes: Experience with the CliniMACS Prodigy

  • Mable Wing Yan Chan PhD Candidate, Arthritis Program , Krembil Research Institute, University Health Network, Institute of Biomaterials and Biomedical Engineering, University of Toronto
  • Sowmya Viswanathan Assistant Professor, Institute of Biomaterial and Biomedical Engineering, Scientist, University of Toronto, Krembil Research Institute, University Health Network

4:15 pm Panel Discussion – Exploring Key Clinical Considerations for Macrophage-directed Therapies

  • Leonard Reyno Chief Executive Officer , Pionyr Immunotherapeutics
  • Igor Feldman Vice President, Head of Computational Biology, Verseau Therapeutics
  • Michael Klichinsky Co-Founder & VP, Discovery, Carisma Therapeutics

4:45 pm Chairman’s Closing Remarks

5:00 pm Close of Summit